Understanding Changes in Established Practice

Caveats in the Established Understanding of CMT1A

Charcot-Marie-Tooth disease type-1A (CMT1A) is one of the most common types of inherited peripheral nerve diseases. It is caused by the trisomy of chromosome 17p12 (c17p12), a large DNA segment of 1.4 Mb containing PMP22 plus eight other genes. The size of c17p12 is formidable for any cloning technique to manipulate, and thus precludes production of models in vitro and in vivo that can precisel...

Ocular inflammatory changes in established multiple sclerosis.

Fifty consecutive patients with clinically definite multiple sclerosis were studied to assess the prevalence of concomitant uveitis. Asymptomatic ocular inflammatory changes were found in nine patients (18%) and appeared to show a positive correlation with severe and progressive disease. Conversely uveitis was uncommon in the presence of established optic atrophy which suggests a negative influ...

Radiation-induced changes in established tumor immunity.

The effect of radiation therapy on tumor growth and on specific immune resistance to tumor growth was investi gated in mice actively sensitized to a syngeneic sarcoma. While radiation was therapeutic for tumor growth in the radiated field, it was also found that extensive-field radia tion, but not limited-field radiation, could facilitate the growth of tumors in unradiated parts of the animal. ...

Understanding theory in clinical practice

Antiplatelet drugs in cardiological practice: Established strategies and new developments

A common pathophysiological course in vascular diseases is an overwhelming activation and aggregation of blood platelets, which results in atherothrombosis. By causing the last decisive step of cerebral, coronary, or peripheral arterial ischemia thrombotic complications of atherosclerotic disease represent a major player in death cause statistics of most western countries. The development of no...